Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Arginine methylation / epigenetic regulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PRMT1 | participates_in | gene | 0.47 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Arginine Methylation Enhancement Therapy | 0.463 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.575
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibi [PMID:40446574] | Chen G, Gou B, Du Y, Zhou Z, Bai Y, Yang | Phytomedicine | 2025 | 1 |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. [PMID:38460517] | Ku B, Eisenbarth D, Baek S, Jeong TK, Ka | Cell Rep Med | 2024 | 1 |
| PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemor [PMID:38383964] | Yamamoto T, Hayashida T, Masugi Y, Oshik | Cancer Res | 2024 | 1 |
| Promising role of protein arginine methyltransferases in overcoming anti-cancer [PMID:37980859] | Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Z | Drug Resist Updat | 2024 | 1 |
| Protein arginine methylation: from enigmatic functions to therapeutic targeting. [PMID:33742187] | Wu Q, Schapira M, Arrowsmith CH, Barsyte | Nat Rev Drug Discov | 2021 | 1 |
| Repression of PRMT activities sensitize human homologous recombination-proficien [PMID:41632514] | ["Zhang Y", "Xu M", "Yuan J", "Hu Z", "J | eLife | 2026 | 0 |
| Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepa [PMID:41501793] | ["Wang Y", "Yuan H", "Yu Y", "Gou X", "W | Journal of translational medic | 2026 | 0 |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therap [PMID:41928257] | Jeong Y, Cho Y, Kim YK | J Biomed Sci | 2026 | 0 |
| Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, [PMID:41801765] | Thiebaut C, Martinez S, Pruvost L, Eve L | Cancer science | 2026 | 0 |
| Potentiating BSEP-mediated bile acid efflux reverses first-line tyrosine kinase [PMID:41903671] | Wu Z, Wang Y, Yu B, Yu R, Chen M, Chen Z | Cancer letters | 2026 | 0 |
| LC-MS profiling of [PMID:41756837] | ["Basirattalab A", "Wallis D", "Hartel N | bioRxiv : the preprint server | 2026 | 0 |
| Discovery of the First-in-Class Protein Arginine Methyltransferase 1 PROTAC Degr [PMID:41830641] | Guo S, Li J, Lin J, Chen Y, Liu C, Liu H | Journal of medicinal chemistry | 2026 | 0 |
| PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulatin [PMID:41912914] | Tian Z, Gao P, Zhang Y, Ma J, Hu X, Wang | Leukemia | 2026 | 0 |
| PFKM governs metabolic shifts throughout skeletal muscle differentiation. [PMID:41735679] | ["Campos M", "Nguyen S", "Kong X", "Yang | Nature metabolism | 2026 | 0 |
| PRMT1-rich exosomes derived from M2 macrophages as novel therapeutics for enhanc [PMID:41610641] | ["Hong H", "Zhou C", "Wang H", "Lin C", | Tissue & cell | 2026 | 0 |
| Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy [PMID:41737591] | ["Yang X", "Zou Y", "Wang H", "Niu Y", " | Sports medicine and health sci | 2026 | 0 |
| Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer g [PMID:41795022] | Zhao W, Wang G, Wang P, Ma B, Liu B, Fu | Oncogene | 2026 | 0 |
| PRMT1-mediated asymmetric dimethylation of arginine residue 602 in DDX1 promotes [PMID:41668296] | ["Liu W", "Liao Y", "Kuai Y", "Gao X", " | Clinical and molecular hepatol | 2026 | 0 |
| Trans-Omic Analysis Identifies the 'PRMT1-STAT3-Integrin αVβ6 Axis' as a Novel T [PMID:41226322] | ["Nishida S", "Ishima T", "Iwami D", "Na | International journal of molec | 2025 | 0 |
| Metformin suppresses gastric cancer progression by disrupting the STAT1-PRMT1 ax [PMID:38876258] | ["Wang K", "Chen Y", "Zhang M", "Wang S" | Biochemical pharmacology | 2024 | 0 |